Syndrome Part 4

Chapter 2

_Sunday, April 5

8:20 A.M.

_"Okay, you'd better take it from here," Winston Bartlett declared to Kenji Noda over the roar of the engine. He had lifted his feet off the pedals and was unbuckling the c.o.c.kpit seat belt. He liked having a turn piloting his McDonnell Douglas 520N helicopter on the commutes between his corporate headquarters in Lower Manhattan and his medical research park in northern New Jersey, but prudence dictated a more experienced hand on the collective during descent and landing. For that he had Noda, formerly of the j.a.panese Defense Forces. A tall, wiry man of few words, Noda was also his bodyguard, chauffeur, and curator of his museum-quality _katana _sword collection.

With the sharp, delicious aroma of the pine forest below wafting through the cabin, Noda quickly put aside the origami he'd been folding, to center his mind and slid around a special opening in the bulkhead. He strapped himself into the seat, then took the radio headphones. The sky was the purest blue, with not another craft in the visual perimeter. They were, after all, over a forest.

As Bartlett settled himself in the pa.s.senger compartment, he thought about where matters stood. There was the very real prospect he had rolled the dice one time too many. The daily blood tests at his clinic in New Jersey were showing he was disturbingly close to using up his nine lives.

To look at him, though, you'd never suspect. At sixty-seven he was still trim and athletic, confident even c.o.c.ky, with a full head of steel dark hair and probing eyes that instantly appraised whatever they caught in their gaze. He played handball at a private health club near his Gramercy Park mansion for an hour every other morning and he routinely defeated men half his age, including Grant Hampton. Remaining a player in every sense of the term was the main reason he enjoyed flying his M-D chopper, even though his license had been lapsed for eight years. It was the perfect embodiment of his l.u.s.t for life. As he never failed to point out, his lifelong business success wasn't bad for a City College grad with a bachelor's degree in Oriental art history.

He had gotten this far because he wanted success enough to make it happen.

He'd started out in New York real estate, but for the last twenty years he had concentrated on buying up small, under- priced medical-device manufacturers with valuable patents and weak bottom lines. He dismantled some of the companies and sold off the pieces, always for more than he'd paid for the whole. Others he restructured with new management, and when a profitable turnaround was in sight, he took them public or sold them to a major player like Johnson & Johnson. The potential winners, though, the ones with promising pipelines of medical devices or drugs whose FDA approval was imminent, he relocated here at the BMD campus in northern New Jersey.

But compet.i.tion was fierce, and the bigger players like Merck and J&J had limitless research capital. They could write off dead ends a lot easier. Thus it was that five years ago, when his pipeline was drying up, Winston Bartlett took the biggest gamble of his life. He acquired a cash-strapped new start-up called the Gerex Corporation, whose head scientist was at the cutting edge of stem cell research. Karl Van de Vliet, M.D., Ph.D., had just had his funding terminated and his laboratory at Stanford University closed after a political flap by right-wingers.

Bartlett had moved Van de Vliet here to New Jersey and poured millions into his stem cell efforts, bleeding BMD's working capital white and racking up 85 million in short-term debt just to keep the rest of the company afloat. Now, though, the gamble was paying off. This month Gerex was winding up stage-three clinical trials for the National Inst.i.tutes of Health. These trials validated a revolutionary procedure that changed the rules of everything known about healing the human body. Already his CFO, Grant Hampton, was heading a negotiating team hammering out a deal with the British biotech conglomerate Cambridge Pharmaceuticals to sell them a 49 percent stake in Gerex. Over 650 million in cash and stock were on the table, and there were escalators, depending on the results of the trials now under way.

The problem was, Cambridge had only seen the financial and summaries of data from Gerex's successful clinical trials. They knew nothing about the fiasco of the Beta procedure.

"Karl called just before we left and said she's worse this morning,"

Bartlett remarked to Noda. He was removing his aviator shades and there was deep frustration in his eyes. "G.o.d I feel so d.a.m.ned responsible.

She was--"

"Having the Beta was Kristen's idea," Noda reminded him. "She wanted to do it."

What he didn't say was on both their minds: what about Bartlett himself? After Kristen Starr had had the Beta, and it had seemed successful, Bartlett decided to have it too. Now his daily blood tests here at the inst.i.tute were showing that the telomerase enzyme was starting to metastasize and replicate in his bloodstream, just as it had in hers.

"Well," Bartlett went on, "Karl thinks he's got a new idea that might save us. Hampton is supposed to be on the case this very morning." He stared out the chopper's window, down at the rooftops of his empire. At the north end of the industrial park was the main laboratory, where stents and t.i.tanium joint replacements were tested on animals--mostly sterile pigs, though some primate testing also was under way. The central area had two large manufacturing facilities where the more complex devices were made.

The buildings were all white cinder block, except for the one they were hovering above now. It was at the far south end, a ma.s.sive three-story mansion nestled among ancient pines and reached by a long cobblestone driveway. Though it was actually the oldest building of the group by a hundred years, it was the latest acquisition for the complex. It fronted a beautiful ten-acre lake, and had been a summer _palacio_ of a nineteenth-century railroad baron. Around mid-century it was turned into a luxury retirement home, complete with nursing services. Its ornate appointments reminded patients of the Frick Gallery, if one could imagine those marble halls teeming with wheelchairs and nurses.

Bartlett had bought the defunct manufacturing complex next to it eighteen years earlier for the BMD industrial park, but it was only six years ago that the owners of the mansion, a group of squabbling heirs, finally relented and agreed to part with the property. It was now a flagship holding of BMD.

He had an eye for design and he had loved remodeling the old mansion and making it into a modern clinic and research facility. He had renamed it the Dorian Inst.i.tute and moved in Karl Van de Vliet and the research staff of the Gerex Corporation. He also had put a landing pad on the expansive roof, along with a stair leading down to an elevator that could take him directly to the laboratory in the bas.e.m.e.nt.

Kenji Noda settled the McDonnell Douglas onto the pad and cut the engines. Bartlett never let himself worry about the noise. The patients in the clinical trials were here at no charge, so they really couldn't complain, particularly since they were now part of what was possibly turning out to be the greatest advance in the history of medicine. If your Alzheimer's had just been reversed at no charge, you weren't going to complain about a little hubbub on the roof.

"I'll wait here," Noda said opening the side door. His bald pate, reminiscent of an eighteenth-century samurai, glistened in the early spring sun.

Bartlett nodded, knowing that his pilot did not trust physicians and hospitals. Taking care of your body was your responsibility, Kenji Noda frequently declared and he trained his own daily. He ate no meat and drank gallons of green tea. When he practiced _kendo_ swordplay, he had the reflexes of a man half his age. He never discussed why he had left j.a.pan, but Bartlett a.s.sumed it was for reasons best left in the dark.

Bartlett headed down the metal stairs leading to the self- service elevator. This daily ordeal of flying out to give a blood sample and to see Kristen was increasingly unsettling. As he inserted his magnetic card into the elevator security box, he felt his hand shaking slightly.

So close to the eternal dream of humankind. So close. How was it going to end?

_Sunday, April 5

8:38 A.M.

_

"Dr. Vee, I'm feeling so much better, I can't tell you." Emma Rosen reached out and caught her physician by the collar of his lab coat, pulling him down and brazenly bussing his cheek. She'd been longing to do this for three weeks but hadn't mustered the nerve until now. "This morning I climbed the stairs to the third floor, twice, up and back without any chest pain. Oy, can you believe? It's a miracle."

Karl Van de Vliet was a couple of inches over six feet, with a trim face and sandy hair that some older patients judged too long for a physician. His English normally was perfect, though sometimes he made a mistake when trying to sound too colloquial. But everyone, young and old adored his retiring Dutch manner and those deep blue eyes that carried some monumental sadness from the past. They also were sure he would soon be recognized worldwide as the miracle worker he was. The prospect of a n.o.bel didn't actually seem that far-fetched.