Medical Essays, 1842-1882 Part 16

Do we gain anything by attempting to get rid of the idea of a special vital force because we find certain mutually convertible relations between forces in the body and out of it? I think not, any more than we should gain by getting rid of the idea and expression Magnetism because of its correlation with electricity. We may concede the unity of all forms of force, but we cannot overlook the fixed differences of its manifestations according to the conditions under which it acts. It is a mistake, however, to think the mystery is greater in an organized body than in any other. We see a stone fall or a crystal form, and there is nothing stranger left to wonder at, for we have seen the Infinite in action.

Just so far as we can recognize the ordinary modes of operation of the common forces of nature,--gravity, cohesion, elasticity, transudation, chemical action, and the rest,--we see the so-called vital acts in the light of a larger range of known facts and familiar a.n.a.logies.

Matteuecci's well-remembered lectures contain many and striking examples of the working of physical forces in physiological processes. Wherever rigid experiment carries us, we are safe in following this lead; but the moment we begin to theorize beyond our strict observation, we are in danger of falling into those mechanical follies which true science has long outgrown.

Recognizing the fact, then, that we have learned nothing but the machinery of life, and are no nearer to its essence, what is it that we have gained by this great discovery of the cell formation and function?

It would have been reward enough to learn the method Nature pursues for its own sake. If the sovereign Artificer lets us into his own laboratories and workshops, we need not ask more than the privilege of looking on at his work. We do not know where we now stand in the hierarchy of created intelligences. We were made a little lower than the angels. I speak it not irreverently; as the lower animals surpa.s.s man in some of their attributes, so it may be that not every angel's eye can see as broadly and as deeply into the material works of G.o.d as man himself, looking at the firmament through an equatorial of fifteen inches' aperture, and searching into the tissues with a twelfth of an inch objective.

But there are other positive gains of a more practical character. Thus we are no longer permitted to place the seat of the living actions in the extreme vessels, which are only the carriers from which each part takes what it wants by the divine right of the omnipotent nucleated cell. The organism has become, in the words already borrowed from Virchow, "a sum of vital unities." The strictum and laxum, the increased and diminished action of the vessels, out of which medical theories and methods of treatment have grown up, have yielded to the doctrine of local cell-communities, belonging to this or that vascular district, from which they help themselves, as contractors are wont to do from the national treasury.

I cannot promise to do more than to select a few of the points of contact between our ignorance and our knowledge which present particular interest in the existing state of our physiological acquisitions.

Some of them involve the microscopic discoveries of which I have been speaking, some belong to the domain of chemistry, and some have relations with other departments of physical science.

If we should begin with the digestive function, we should find that the long-agitated question of the nature of the acid of the gastric juice is becoming settled in favor of the lactic. But the whole solvent agency of the digestive fluid enters into the category of that exceptional mode of action already familiar to us in chemistry as catalysis. It is therefore doubly difficult of explanation; first, as being, like all reactions, a fact not to be accounted for except by the imaginative appeal to "affinity," and secondly, as being one of those peculiar reactions provoked by an element which stands outside and looks on without compromising itself.

The doctrine of Mulder, so widely diffused in popular and scientific belief, of the existence of a common base of all alb.u.minous substances, the so-called protein, has not stood the test of rigorous a.n.a.lysis. The division of food into azotized and non-azotized is no doubt important, but the attempt to show that the first only is plastic or nutritive, while the second is simply calorifacient, or heat-producing, fails entirely in the face of the facts revealed by the study of man in different climates, and of numerous experiments in the feeding of animals. I must return to this subject in connection with the respiratory function.

The sugar-making faculty of the liver is another "catalytic" mystery, as great as the rest of them, and no greater. Liver-tissue brings sugar out of the blood, or out of its own substance;--why?

Quia est in eo Virtus saccharitiva.

Just what becomes of the sugar beyond the fact of its disappearance before it can get into the general circulation and sweeten our tempers, it is hard to say.

The pancreatic fluid makes an emulsion of the fat contained in our food, but just how the fatty particles get into the villi we must leave Brucke and Kolliker to settle if they can.

No one has shown satisfactorily the process by which the blood-corpuscles are formed out of the lymph-corpuscles, nor what becomes of them. These two questions are like those famous household puzzles,--Where do the flies come from? and, Where do the pins go to?

There is a series of organs in the body which has long puzzled physiologists,--organs of glandular aspect, but having no ducts,--the spleen, the thyroid and thymus bodies, and the suprarenal capsules. We call them vascular glands, and we believe that they elaborate colored and uncolored blood-cells; but just what changes they effect, and just how they effect them, it has proved a very difficult matter to determine. So of the noted glandules which form Peyer's patches, their precise office, though seemingly like those of the lymphatic glands, cannot be positively a.s.signed, so far as I know, at the present time.

It is of obvious interest to learn it with reference to the pathology of typhoid fever. It will be remarked that the coincidence of their changes in this disease with enlargement of the spleen suggests the idea of a similarity of function in these two organs.

The theories of the production of animal heat, from the times of Black, Lavoisier, and Crawford to those of Liebig, are familiar to all who have paid any attention to physiological studies. The simplicity of Liebig's views, and the popular form in which they have been presented, have given them wide currency, and incorporated them in the common belief and language of our text-books. Direct oxidation or combustion of the carbon and hydrogen contained in the food, or in the tissues themselves; the division of alimentary substances into respiratory, or non-azotized, and azotized,--these doctrines are familiar even to the cla.s.ses in our high-schools. But this simple statement is boldly questioned. Nothing proves that oxygen combines (in the system) with hydrogen and carbon in particular, rather than with sulphur and azote. Such is the well-grounded statement of Robin and Verdeil. "It is very probable that animal heat is entirely produced by the chemical actions which take place in the organism, but the phenomenon is too complex to admit of our calculating it according to the quality of oxygen consumed." These last are the words of Regnault, as cited by Mr. Lewes, whose intelligent discussion of this and many of the most interesting physiological problems I strongly recommend to your attention.

This single ill.u.s.tration covers a wider ground than the special function to which it belongs. We are learning that the chemistry of the body must be studied, not simply by its ingesta and egesta, but that there is a long intermediate series of changes which must be investigated in their own light, under their own special conditions. The expression "sum of vital unities" applies to the chemical actions, as well as to other actions localized in special parts; and when the distinguished chemists whom I have just cited ent.i.tle their work a treatise on the immediate principles of the body, they only indicate the nature of that profound and subtile a.n.a.lysis which must take the place of all hasty generalizations founded on a comparison of the food with residual products.

I will only call your attention to the fact, that the exceptional phenomenon of the laboratory is the prevailing law of the organism.

Nutrition itself is but one great catalytic process. As the blood travels its rounds, each part selects its appropriate element and transforms it to its own likeness. Whether the appropriating agent be cell or nucleus, or a structureless solid like the intercellular substance of cartilage, the fact of its presence determines the separation of its proper const.i.tuents from the circulating fluid, so that even when we are wounded bone is replaced by bone, skin by skin, and nerve by nerve.

It is hardly without a smile that we resuscitate the old question of the 'vis insita' of the muscular fibre, so famous in the discussions of Haller and his contemporaries. Speaking generally, I think we may say that Haller's doctrine is the one now commonly received; namely, that the muscles contract in virtue of their own inherent endowments. It is true that Kolliker says no perfectly decisive fact has been brought forward to prove that the striated muscles contract without having been acted on by nerves. Yet Mr. Bowman's observations on the contraction of isolated fibres appear decisive enough (unless we consider them invalidated by Dr. Lionel Beale's recent researches), tending to show that each elementary fibre is supplied with nerves; and as to the smooth muscular fibres, we have Virchow's statement respecting the contractility of those of the umbilical cord, where there is not a trace of any nerves.

In the investigation of the nervous system, anatomy and physiology have gone hand in hand. It is very singular that so important, and seemingly simple, a fact as the connection of the nerve-tubes, at their origin or in their course, with the nerve-cells, should have so long remained open to doubt, as you may see that it did by referring to the very complete work of Sharpey and Quain (edition of 1849), the histological portion of which is cordially approved by Kolliker himself.

Several most interesting points of the minute anatomy of the nervous centres have been laboriously and skilfully worked out by a recent graduate of this Medical School, in a monograph worthy to stand in line with those of Lockhart Clarke, Stilling, and Schroder van der Kolk. I have had the privilege of examining and of showing some of you a number of Dr. Dean's skilful preparations. I have no s.p.a.ce to give even an abstract of his conclusions. I can only refer to his proof of the fact, that a single cell may send its processes into several different bundles of nerve-roots, and to his demonstration of the curved ascending and descending fibres from the posterior nerveroots, to reach what he has called the longitudinal columns of the cornea. I must also mention Dr.

Dean's exquisite microscopic photographs from sections of the medulla oblongata, which appear to me to promise a new development, if not a new epoch, in anatomical art.

It having been settled that the nerve-tubes can very commonly be traced directly to the nerve-cells, the object of all the observers in this department of anatomy is to follow these tubes to their origin. We have an infinite snarl of telegraph wires, and we may be reasonably sure, that, if we can follow them up, we shall find each of them ends in a battery somewhere. One of the most interesting problems is to find the ganglionic origin of the great nerves of the medulla oblongata, and this is the end to which, by the aid of the most delicate sections, colored so as to bring out their details, mounted so as to be imperishable, magnified by the best instruments, and now self-recorded in the light of the truth-telling sunbeam, our fellow-student is making a steady progress in a labor which I think bids fair to rank with the most valuable contributions to histology that we have had from this side of the Atlantic.

It is interesting to see how old questions are incidentally settled in the course of these new investigations. Thus, Mr. Clarke's dissections, confirmed by preparations of Mr. Dean's which I have myself examined, placed the fact of the decussation of the pyramids--denied by Haller, by Morgagni, and even by Stilling--beyond doubt. So the spinal ca.n.a.l, the existence of which, at least in the adult, has been so often disputed, appears as a coa.r.s.e and unequivocal anatomical fact in many of the preparations referred to.

While these studies of the structure of the cord have been going on, the ingenious and indefatigable Brown-Sequard has been investigating the functions of its different parts with equal diligence. The microscopic anatomists had shown that the ganglionic corpuscles of the gray matter of the cord are connected with each other by their processes, as well as with the nerve-roots. M. Brown-Sequard has proved by numerous experiments that the gray substance transmits sensitive impressions and muscular stimulation. The oblique ascending and descending fibres from the posterior nerve-roots, joining the "longitudinal columns of the cornua," account for the results of Brown-Sequard's sections of the posterior columns. The physiological experimenter has also made it evident that the decussation of the conductors of sensitive impressions has its seat in the spinal core, and not in the encephalon, as had been supposed. Not less remarkable than these results are the facts, which I with others of my audience have had the opportunity of observing, as shown by M. Brown-Sequard, of the artificial production of epilepsy in animals by injuring the spinal cord, and the induction of the paroxysm by pinching a certain portion of the skin. I would also call the student's attention to his account of the relations of the nervous centres to nutrition and secretion, the last of which relations has been made the subject of an extended essay by our fellow countryman, Dr. H.

F. Campbell of Georgia.

The physiology of the spinal cord seems a simple matter as you study it in Longet. The experiments of Brown-Sequard have shown the problem to be a complex one, and raised almost as many doubts as they have solved questions; at any rate, I believe all lecturers on physiology agree that there is no part of their task they dread so much as the a.n.a.lysis of the evidence relating to the special offices of the different portions of the medulla spinalis. In the brain we are sure that we do not know how to localize functions; in the spinal cord, we think we do know something; but there are so many anomalies, and seeming contradictions, and sources of fallacy, that beyond the facts of crossed paralysis of sensation, and the conducting agency of the gray substance, I am afraid we retain no cardinal principles discovered since the development of the reflex function took its place by Sir Charles Bell's great discovery.

By the manner in which I spoke of the brain, you will see that I am obliged to leave phrenology sub Jove,--out in the cold,--as not one of the household of science. I am not one of its haters; on the contrary, I am grateful for the incidental good it has done. I love to amuse myself in its plaster Golgothas, and listen to the glib professor, as he discovers by his manipulations

"All that disgraced my betters met in me."

I loved of old to see square-headed, heavy-jawed Spurzheim make a brain flower out into a corolla of marrowy filaments, as Vieussens had done before him, and to hear the dry-fibred but human-hearted George Combe teach good sense under the disguise of his equivocal system. But the pseudo-sciences, phrenology and the rest, seem to me only appeals to weak minds and the weak points of strong ones. There is a pica or false appet.i.te in many intelligences; they take to odd fancies in place of wholesome truth, as girls gnaw at chalk and charcoal. Phrenology juggles with nature. It is so adjusted as to soak up all evidence that helps it, and shed all that harms it. It crawls forward in all weathers, like Richard Edgeworth's hygrometer. It does not stand at the boundary of our ignorance, it seems to me, but is one of the will-o'-the-wisps of its undisputed central domain of bog and quicksand. Yet I should not have devoted so many words to it, did I not recognize the light it has thrown on human actions by its study of congenital organic tendencies. Its maps of the surface of the head are, I feel sure, founded on a delusion, but its studies of individual character are always interesting and instructive.

The "snapping-turtle" strikes after its natural fashion when it first comes out of the egg. Children betray their tendencies in their way of dealing with the b.r.e.a.s.t.s that nourish them; nay, lean venture to affirm, that long before they are born they teach their mothers something of their turbulent or quiet tempers.

"Castor gaudet equis, ovo proanatus eodem Pugnis."

Strike out the false pretensions of phrenology; call it anthropology; let it study man the individual in distinction from man the abstraction, the metaphysical or theological lay-figure; and it becomes "the proper study of mankind," one of the n.o.blest and most interesting of pursuits.

The whole physiology of the nervous system, from the simplest manifestation of its power in an insect up to the supreme act of the human intelligence working through the brain, is full of the most difficult yet profoundly interesting questions. The singular relations between electricity and nerve-force, relations which it has been attempted to interpret as meaning ident.i.ty, in the face of palpable differences, require still more extended studies. You may be interested by Professor Faraday's statement of his opinion on the matter. "Though I am not satisfied that the nervous fluid is only electricity, still I think that the agent in the nervous system maybe an inorganic force; and if there be reason for supposing that magnetism is a higher relation of force than electricity, so it may well be imagined that the nervous power may be of a still more exalted character, and yet within the reach of experiment."

In connection with this statement, it is interesting to refer to the experiments of Helmholtz on the rapidity of transmission of the nervous actions. The rate is given differently in Valentin's report of these experiments and in that found in the "Scientific Annual" for 1858.

One hundred and eighty to three hundred feet per second is the rate of movement a.s.signed for sensation, but all such results must be very vaguely approximative. Boxers, fencers, players at the Italian game of morn, "prestidigitators," and all who depend for their success on rapidity of motion, know what differences there are in the personal equation of movement.

Reflex action, the mechanical sympathy, if I may so call it, of distant parts; Instinct, which is crystallized intelligence,--an absolute law with its invariable planes and angles introduced into the sphere of consciousness, as raphides are inclosed in the living cells of plants; Intellect,--the operation of the thinking principle through material organs, with an appreciable waste of tissue in every act of thought, so that our clergymen's blood has more phosphates to get rid of on Monday than on any other day of the week; Will,--theoretically the absolute determining power, practically limited in different degrees by the varying organization of races and individuals, annulled or perverted by different ill-understood organic changes; on all these subjects our knowledge is in its infancy, and from the study of some of them the interdict of the Vatican is hardly yet removed.

I must allude to one or two points in the histology and physiology of the organs of sense. The anterior continuation of the retina beyond the ora serrata has been a subject of much discussion. If H. Muller and Kolliker can be relied upon, this question is settled by recognizing that a layer of cells, continued from the retina, pa.s.ses over the surface of the zonula Zinnii, but that no proper nervous element is so prolonged forward.

I observe that Kolliker calls the true nervous elements of the retina "the layer of gray cerebral substance." In fact, the ganglionic corpuscles of each eye may be considered as const.i.tuting a little brain, connected with the ma.s.ses behind by the commissure, commonly called the optic nerve. We are prepared, therefore, to find these two little brains in the most intimate relations with each other, as we find the cerebral hemispheres. We know that they are directly connected by fibres that arch round through the chiasma.

I mention these anatomical facts to introduce a physiological observation of my own, first announced in one of the lectures before the Medical Cla.s.s, subsequently communicated to the American Academy of Arts and Sciences, and printed in its "Transactions" for February 14, 1860.

I refer to the apparent transfer of impressions from one retina to the other, to which I have given the name reflex vision. The idea was suggested to me in consequence of certain effects noticed in employing the stereoscope. Professor William B. Rodgers has since called the attention of the American Scientific a.s.sociation to some facts bearing on the subject, and to a very curious experiment of Leonardo da Vinci's, which enables the observer to look through the palm of his hand (or seem to), as if it had a hole bored through it. As he and others hesitated to accept my explanation, I was not sorry to find recently the following words in the "Observations on Man" of that acute observer and thinker, David Hartley. "An impression made on the right eye alone by a single object may propagate itself into the left, and there raise up an image almost equal in vividness to itself; and consequently when we see with one eye only, we may, however, have pictures in both eyes." Hartley, in 1784, had antic.i.p.ated many of the doctrines which have since been systematized into the theory of reflex actions, and with which I have attempted to a.s.sociate this act of reflex vision. My sixth experiment, however, in the communication referred to, appears to me to be a crucial one, proving the correctness of my explanation, and I am not aware that it has been before inst.i.tuted.

Another point of great interest connected with the physiology of vision, and involved for a long time in great obscurity, is that of the adjustment of the eye to different distances. Dr. Clay Wallace of New York, who published a very ingenious little book on the eye about twenty years ago, with vignettes reminding one of Bewick, was among the first, if not the first, to describe the ciliary muscle, to which the power of adjustment is generally ascribed. It is ascertained, by exact experiment with the phacueidoscope, that accommodation depends on change of form of the crystalline lens. Where the crystalline is wanting, as Mr. Ware long ago taught, no power of accommodation remains. The ciliary muscle is generally thought to effect the change of form of the crystalline. The power of accommodation is lost after the application of atropine, in consequence, as is supposed, of the paralysis of this muscle. This, I believe, is the nearest approach to a demonstration we have on this point.

I have only time briefly to refer to Professor Draper's most ingenious theory as to the photographic nature of vision, for an account of which I must refer to his original and interesting Treatise on Physiology.

It were to be wished that the elaborate and very interesting researches of the Marquis Corti, which have revealed such singular complexity of structure in the cochlea of the ear, had done more to clear up its doubtful physiology; but I am afraid we have nothing but hypotheses for the special part it plays in the act of hearing, and that we must say the same respecting the office of the semicircular ca.n.a.ls.

The microscope has achieved some of its greatest triumphs in teaching us the changes which occur in the development of the embryo. No more interesting discovery stands recorded in the voluminous literature of this subject than the one originally announced by Martin Barry, afterwards discredited, and still later confirmed by Mr. Newport and others; namely the fact that the fertilizing filament reaches the interior of the ovum in various animals;--a striking parallel to the action of the pollen-tube in the vegetable. But beyond the mechanical facts all is mystery in the movements of organization, as profound as in the fall of a stone or the formation of a crystal.

To the chemist and the microscopist the living body presents the same difficulties, arising from the fact that everything is in perpetual change in the organism. The fibrine of the blood puzzles the one as much as its globules puzzle the other. The difference between the branches of science which deal with s.p.a.ce only, and those which deal with s.p.a.ce and time, is this: we have no gla.s.ses that can magnify time. The figure I here show you a was photographed from an object (pleurosigma angulatum) magnified a thousand diameters, or presenting a million times its natural surface. This other figure of the same object, enlarged from the one just shown, is magnified seven thousand diameters, or forty-nine million times in surface. When we can make the forty-nine millionth of a second as long as its integer, physiology and chemistry will approach nearer the completeness of anatomy.

Our reverence becomes more worthy, or, if you will, less unworthy of its Infinite Object in proportion as our intelligence is lifted and expanded to a higher and broader understanding of the Divine methods of action.

If Galen called his heathen readers to admire, the power, the wisdom, the providence, the goodness of the "Framer of the animal body,"--if Mr.

Boyle, the student of nature, as Addison and that friend of his who had known him for forty years tell us, never uttered the name of the Supreme Being without making a distinct pause in his speech, in token of his devout recognition of its awful meaning,--surely we, who inherit the acc.u.mulated wisdom of nearly two hundred years since the time of the British philosopher, and of almost two thousand since the Greek physician, may well lift our thoughts from the works we study to their great Artificer. These wonderful discoveries which we owe to that mighty little instrument, the telescope of the inner firmament with all its included worlds; these simple formulae by which we condense the observations of a generation in a single axiom; these logical a.n.a.lyses by which we fence out the ignorance we cannot reclaim, and fix the limits of our knowledge,--all lead us up to the inspiration of the Almighty, which gives understanding to the world's great teachers. To fear science or knowledge, lest it disturb our old beliefs, is to fear the influx of the Divine wisdom into the souls of our fellow-men; for what is science but the piecemeal revelation,--uncovering,--of the plan of creation, by the agency of those chosen prophets of nature whom G.o.d has illuminated from the central light of truth for that single purpose?

The studies which we have glanced at are preliminary in your education to the practical arts which make use of them,--the arts of healing,--surgery and medicine. The more you examine the structure of the organs and the laws of life, the more you will find how resolutely each of the cell-republics which make up the E pluribus unum of the body maintains its independence. Guard it, feed it, air it, warm it, exercise or rest it properly, and the working elements will do their best to keep well or to get well. What do we do with ailing vegetables? Dr. Warren, my honored predecessor in this chair, bought a country-place, including half of an old orchard. A few years afterwards I saw the trees on his side of the fence looking in good health, while those on the other side were scraggy and miserable. How do you suppose this change was brought about? By watering them with Fowler's solution? By digging in calomel freely about their roots? Not at all; but by loosening the soil round them, and supplying them with the right kind of food in fitting quant.i.ties.

Now a man is not a plant, or, at least, he is a very curious one, for he carries his soil in his stomach, which is a kind--of portable flower-pot, and he grows round it, instead of out of it. He has, besides, a singularly complex nutritive apparatus and a nervous system.

But recollect the doctrine already enunciated in the language of Virchow, that an animal, like a tree, is a sum of vital unities, of which the cell is the ultimate element. Every healthy cell, whether in a vegetable or an animal, necessarily performs its function properly so long as it is supplied with its proper materials and stimuli. A cell may, it is true, be congenitally defective, in which case disease is, so to speak, its normal state. But if originally sound and subsequently diseased, there has certainly been some excess, deficiency, or wrong quality in the materials or stimuli applied to it. You remove this injurious influence and subst.i.tute a normal one; remove the baked coal-ashes, for instance, from the roots of a tree, and replace them with loam; take away the salt meat from the patient's table, and replace it with fresh meat and vegetables, and the cells of the tree or the man return to their duty.