Darwin's Children Part 58

Sequencing: determining the sequence of molecules in a polymer such as a protein or nucleic acid; in genetics, discovering the sequence of bases in a gene or a length of DNA or RNA, or in the genome as a whole. Research into the sequence of the entire human genome has made huge strides, but our understanding of the implications of this growing knowledge is in its infancy. determining the sequence of molecules in a polymer such as a protein or nucleic acid; in genetics, discovering the sequence of bases in a gene or a length of DNA or RNA, or in the genome as a whole. Research into the sequence of the entire human genome has made huge strides, but our understanding of the implications of this growing knowledge is in its infancy.

s.e.x chromosomes: in humans, the X and Y chromosomes. Two X chromosomes results in a female; an X and a Y results in a male. Other species have different types of s.e.x chromosomes. in humans, the X and Y chromosomes. Two X chromosomes results in a female; an X and a Y results in a male. Other species have different types of s.e.x chromosomes.

Shiver: hypothetical activation of dormant endogenous retroviruses in women who have undergone SHEVA pregnancies. Recombination of exogenous and endogenous viral genes may produce new viruses with an unknown pathogenic potential. hypothetical activation of dormant endogenous retroviruses in women who have undergone SHEVA pregnancies. Recombination of exogenous and endogenous viral genes may produce new viruses with an unknown pathogenic potential.

Transposon: see see mobile elements mobile elements.

Vaccine: a substance that produces an immune response to a disease-causing organism. See a substance that produces an immune response to a disease-causing organism. See antibody antibody, antigen, immune response antigen, immune response.

Virion: infectious virus particle. infectious virus particle.

Virus: nonliving but organically active particle capable of entering a cell and commandeering the cell's reproductive capacity to produce more viruses. Viruses consist of DNA or RNA, usually surrounded by a protein coat, or capsid. This capsid may in turn be surrounded by an envelope. There are hundreds of thousands of known viruses, and potentially millions not yet described. See nonliving but organically active particle capable of entering a cell and commandeering the cell's reproductive capacity to produce more viruses. Viruses consist of DNA or RNA, usually surrounded by a protein coat, or capsid. This capsid may in turn be surrounded by an envelope. There are hundreds of thousands of known viruses, and potentially millions not yet described. See exogenous virus exogenous virus, ERV. ERV.

Vomeronasal organ (VNO, also known as Jacobson's organ): consisting of two pitlike openings in the roof of the mouth or in the nasal septum, this organ, in non-human mammals, provides a pathway that links pheromones to a hormone response and to s.e.x differences in behavior consisting of two pitlike openings in the roof of the mouth or in the nasal septum, this organ, in non-human mammals, provides a pathway that links pheromones to a hormone response and to s.e.x differences in behavior. "Frithing" is a term used to describe sucking in air over the pit-like entrance to this organ, which is in the roof of the mouth in some animals. Cats can sometimes be observed curling their upper lip when smelling something funky; this is also called the flehman response, usually a.s.sociated with examination of urine, marking scents, etc. Snakes perform similar sampling by drawing in scents from the air on their flicking tongues. Humans have vomeronasal pits, though they are very small and somewhat difficult to find; they may play a role in mate choice and other behaviors. A 1995 journal article warned plastic surgeons to preserve the human vomeronasal organ during reconstructive surgery, lest damage lead to loss of s.e.xual interest and subsequent litigation. "Frithing" is a term used to describe sucking in air over the pit-like entrance to this organ, which is in the roof of the mouth in some animals. Cats can sometimes be observed curling their upper lip when smelling something funky; this is also called the flehman response, usually a.s.sociated with examination of urine, marking scents, etc. Snakes perform similar sampling by drawing in scents from the air on their flicking tongues. Humans have vomeronasal pits, though they are very small and somewhat difficult to find; they may play a role in mate choice and other behaviors. A 1995 journal article warned plastic surgeons to preserve the human vomeronasal organ during reconstructive surgery, lest damage lead to loss of s.e.xual interest and subsequent litigation.

Vomeropherin: a marketing term for a pheromone detected by the human vomeronasal organ (the same as a mammalian pheromone detected by the mammalian VNO). a marketing term for a pheromone detected by the human vomeronasal organ (the same as a mammalian pheromone detected by the mammalian VNO).

Xenotransplant: transplant of nonhuman tissues and organs into humans. Xenotransplants in the past have involved baboon and other ape organs. Most xenotransplant research now focuses on pig tissues and organs. Xenotransplants could be risky because of the existence of latent viruses within the donor tissues. (See transplant of nonhuman tissues and organs into humans. Xenotransplants in the past have involved baboon and other ape organs. Most xenotransplant research now focuses on pig tissues and organs. Xenotransplants could be risky because of the existence of latent viruses within the donor tissues. (See ERV ERV, herpes, PERV herpes, PERV.) The case of Mrs. Carla Rhine described in this novel is unlikely in real life; Mrs. Rhine's maladies come from the unfortunate combination of a relatively rare evolutionary viral event and transplantation. Nevertheless, the possibilities of viral contamination or viral recombination within human recipients of animal tissues is very real, and demands further research.

ACKNOWLEDGMENTS.

Special thanks to Mark Minie, Ph.D., and Rose James, Ph.D.; Deirdre V. Lovecky, Ph.D.; Dr. Joseph Miller; Dominic Esposito of the National Cancer Inst.i.tute; Dr. Elizabeth Kutter; Cleone Hawkinson; Alison Stenger, Ph.D.; David and Diane Clark; Brian W. J. Mahy, Ph.D., Sc.D., director of the Division of Viral and Rickettsial Diseases at the Center for Disease Control; Karl H. Anders, M.D.; Sylvia Anders, M.D.; Howard Bloom and the International Paleopsychology Project; Cynthia Robbins-Roth, Ph.D., James V. Kohl, Oliver Morton, Karen Anderson, Lynn Caporale, and Roger Brent, Ph.D.

A BRIEF READING LIST.

A concise, elegantly written and conservative view of neo-Darwinian evolutionary theory is available in Richard Dawkins's concise, elegantly written and conservative view of neo-Darwinian evolutionary theory is available in Richard Dawkins's River out of Eden: A Darwinian View of Life River out of Eden: A Darwinian View of Life, BasicBooks, 1995. Dawkins is one of our best science writers and an excellent whetstone for anyone wishing to challenge inst.i.tutionalized views of biology and evolution. It is my belief that he is wrong on many points, but he defines the debate in ways few others can.

Published more recently, and going into more detail, Ernst Mayr's summing up of a life's work, What Evolution Is What Evolution Is (2002, Perseus Books) makes another clear and unyielding statement of the paradigm of modern Darwinism. There will probably be no finer exponents of the old view of Darwinian evolution. (2002, Perseus Books) makes another clear and unyielding statement of the paradigm of modern Darwinism. There will probably be no finer exponents of the old view of Darwinian evolution.

The new view is emerging even as we speak.

Stephen Jay Gould is unfortunately no longer with us. I recommend all of his learned and impa.s.sioned books and essays, but in particular the flawed, and for that reason no less fascinating and instructive, Wonderful Life Wonderful Life (Norton, 1989). (Norton, 1989).

A good bridge to a larger understanding of the turmoil in evolutionary theory is Niles Eldredge's Reinventing Darwin: The Great Debate at the High Table of Evolutionary Theory Reinventing Darwin: The Great Debate at the High Table of Evolutionary Theory, Wiley, 1995. Eldredge and Gould are currently credited with a particular view of evolutionary leaps known as punctuated equilibrium punctuated equilibrium, but the idea can be traced back at least to masters such as Ernst Mayr, and even back to Darwin. Wherever it comes from, punctuated equilibrium was one of the key stimuli to my writing Darwin's Radio. Darwin's Radio. Gould and Eldredge should not be blamed for my elaborations, however. Gould and Eldredge should not be blamed for my elaborations, however.

Peter J. Bowler's The Non-Darwinian Revolution: Reinterpreting a Historical Myth The Non-Darwinian Revolution: Reinterpreting a Historical Myth (1988, Johns Hopkins) is scholarly and entertaining at once. (1988, Johns Hopkins) is scholarly and entertaining at once.

A fine introduction to genetics is Dealing with Genes: The Language of Heredity Dealing with Genes: The Language of Heredity by Paul Berg and Maxine Singer, 1992, University Science Books. Though a decade old, its information is still useful and its att.i.tude is forward-looking. It could prepare the reader for the following books. by Paul Berg and Maxine Singer, 1992, University Science Books. Though a decade old, its information is still useful and its att.i.tude is forward-looking. It could prepare the reader for the following books.

Lynn Margulis and Dorion Sagan have published an excellent critique of neo-Darwinianism in Acquiring Genomes: A Theory on the Origins of Species Acquiring Genomes: A Theory on the Origins of Species, 2002, BasicBooks. Margulis is a pioneer in thinking about cooperative and symbiotic systems, and she and her son Dorion make up the single most stimulating popular writing team in modern biology.

More radical still, but just as polite and level-headed as Margulis, is Lynn Caporale, whose Darwin in the Genome: Molecular Strategies in Biological Evolution Darwin in the Genome: Molecular Strategies in Biological Evolution (2003, McGraw-Hill) is a clear and thoughtful examination of how genomics will shape and mutate the debate on evolution. (2003, McGraw-Hill) is a clear and thoughtful examination of how genomics will shape and mutate the debate on evolution.

Lamarck's Signature: How Retrogenes are Changing Darwin's Natural Selection Paradigm, by Edward J. Steele, Robyn A. Lindley, and Robert V. Blanden (1998, Perseus Books) focuses on one possible cause and arbiter of genomic variation.

A key text in modern biology is Retroviruses Retroviruses, edited by John M. Coffin, Stephen H. Hughes, and Harold E. Varmus, 1997, Cold Spring Harbor Laboratory Press. Mostly for professionals, this rigorous and pioneering collection of monographs is filled with useful information.

Of particular relevance to my two novels is Lateral DNA Transfer Lateral DNA Transfer by Frederic Bushman, 2002, Cold Spring Harbor Laboratory Press, is an important synopsis of what is currently known about DNA transfer through viruses, transposons, plasmids, etc. I think it is one of the most significant biology books published in the last decade. by Frederic Bushman, 2002, Cold Spring Harbor Laboratory Press, is an important synopsis of what is currently known about DNA transfer through viruses, transposons, plasmids, etc. I think it is one of the most significant biology books published in the last decade.

James V. Kohl's The Scent of Eros The Scent of Eros (1995; reprinted in a revised edition, 2002, Continuum) is a rich source of information on pheromones, human communication through smell, and the influence of scent on s.e.xuality. (1995; reprinted in a revised edition, 2002, Continuum) is a rich source of information on pheromones, human communication through smell, and the influence of scent on s.e.xuality.

There's a wealth of fine writing on these topics in many other popular science books, textbooks, and magazines. Searching on author names and topics in online bookstores can be a good way to leapfrog through diverse subjects. Which leads us to a very small sampling of Web sites.

Searching on key words in Web engines such as Google ("HERV," "Retrotransposon," "Barbara McClintock," "h.o.m.o erectus," "Mitochondria," etc.) can lead the curious reader into a combination paradise and mine field of articles peer-reviewed and otherwise, research goals and updates, opinions, and quite a few rants of varying degrees of erudition. Caveats abound-there are dozens if not hundreds of Creationist and other religiously motivated, anti-evolution sites that seem to discuss evolution and genetics with some lucidity, for a while. Generally speaking, the science here is dubious at best.

Nevertheless, searching on Google is how I located excellent articles by Luis P. Villarreal. In particular, I was influenced by Villarreal's "The Viruses That Make Us: A Role For Endogenous Retrovirus In The Evolution Of Placental Species," available on the Web at http:// darwin.bio.uci.edu/ ~faculty/ villarreal/ new1/ erv-placental.html (Dr. Villarreal, Eric Larsson, and Howard Temin should not, however, be blamed for all the uses their ideas are put to in this novel.) James V. Kohl's Web site, www.pheromones.com, provides a number of links to articles and other sites that discuss the biology of smell. The Web site of the Molecular Sciences Inst.i.tute, www.molsci.org, is filled with interesting news and developments. The International Paleopsychology Project, www.paleopsych.org, is a clearing house of fascinating ideas with many links to other Web sites.

Periodically, I will post bibliographical updates on www.gregbear.com, as well as comments from readers about the theoretical underpinnings of the Darwin Darwin novels. novels.

Also by Greg Bear Hegira Beyond Heaven River Strength of Stone Psychlone Blood Music Songs of Earth and Power Eon Eternity Legacy The Forge of G.o.d Anvil of Stars Queen of Angels / (Slant) Heads Moving Mars Dinosaur Summer Foundation and Chaos Star Wars: Rogue Planet Darwin's Radio Vitals