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A hyphenated cla.s.sification thus becomes inevitable. Especially is this so if the two glands are mutually antagonistic and inhibitory.
A compromise effect is then necessitated. Or an individual may be dominated by one gland at one period of his life and by another at a later period. One of the glands, the thyroid, for example, will show, by the traces it has left upon the earliest developing features, that it was in control at the very earliest dates of his history, while other signs will disclose the more recent influence of the adrenal or of the pituitary. The combination becomes cla.s.sifiable as the thyroid-pituitary type, or as the thyroid-adrenal type.
That the external features as well as the chronic diseases of human beings are controlled by some common factor has long been suspected.
Inquiries into morbid phenomena with a hereditary trend yielded information that has paved the way for the internal secretion theory.
It has long been known that certain diseases effect only certain individuals of a definite const.i.tution. Apoplexy, diabetes, arteriosclerosis, Bright's disease, are met with almost exclusively in what the older clinicians talked about as the apopleptic type. On the other hand, they said, anemias, tuberculosis, hemophilias, scrofulas occurred more among the lymphatic type. But they had no idea whatever of the true functional basis of the two different types. The truth as we of today view it is that these two types represent different textures of human beings, fabricated of different internal secretions.
They are really two different breeds of the species h.o.m.o Sapiens. The materials being different, the color and feel of them is different, and the resistance to wear and tear is different.
ENDOCRINE a.n.a.lYSIS
The modes of cla.s.sification glimpsed at are certainly exceedingly broad and sweeping. It is well enough to establish types and cla.s.ses.
But beneath them are sheltered the infinite possibilities of permutations and combinations, which explain the countless variety and complexity of form and function. Every individual born among the vertebrates, for example, must have a certain definite amount and percentage of pituitary gland, anterior and posterior, pineal, thyroid, parathyroid, thymus, adrenal, pancreas, interst.i.tial and so on. Now if, to state it in terms of percentages, for the sake of argument, the pituitary is 25, the pineal 10, the thyroid 36, the parathyroids 15, the thymus 29, the adrenals 60, the pancreas 49, the interst.i.tials 72 (the gland when acting maximally to be graded as 100), we see at once how different such an individual must be from one who has, say, pituitary 84, pineal 39, thyroid 26, parathyroid 42, adrenals 96, pancreas 22 and interst.i.tials 89. One obtains at once from the contrasts of such figures some idea of the possibilities. As each point plus or minus must count to produce some difference in the individual, the results are manifest. Varying within the numerical limits imposed by genus, species, variety and family (which limits are probably responsible for the persistence of the particular genus, species, variety, or family) the individual becomes an individual because of the relative values of the percentages in his blood and tissues of these different internal secretions. We thus begin to gain an insight into the patterns according to which men, women and animals are woven.
We are, as yet, far from an exact endocrine a.n.a.lysis of the individual. But we know that the endocrines rule over growth and nutrition, a vast dominion which incorporates every organ and every tissue. By enhancing or r.e.t.a.r.ding the nutritional changes, the growth of the organ or tissue is favored or restricted. The size and shape of an individual, as a whole, as well as of the specialized cell ma.s.ses composing him, as hands and feet, the nose and ears, and so on, are therefore controlled by them. Whether an organism is to be tall or short, lean or corpulent, graceful or awkward, is decided by their interactions. These, like human covenants, vary with the different reactions of the parties to the contract. And so a great deal depends upon whether they work harmoniously or discordantly, and upon which does the most work and which the least.
Undersecretion and Oversecretion
It is when a gland, either in the course of development, or because of the influence of starvation, shock, injury, poisoning or infection, begins to undersecrete or oversecrete that its effects upon growth and nutrition become grossly manifest. A veritable transfiguration of the individual may occur, the black magic of which may perplex him for a lifetime. A man, made eunuchoid by an accident or by mumps, will observe in himself astonishing changes in his const.i.tutional make-up, mentality and s.e.xuality. He would be more astounded to learn that beneath the appearances, the changes, so alarming him, there are profound alterations in the rate at which he is taking in oxygen, burning up sugar, acc.u.mulating carbon dioxide and excreting waste byproducts through the kidneys, which are responsible for them.
The differences between the normal and abnormal are only a matter of degree. And so, to be sure, are differences between types. But it is hard to realize that the striking distinctions between the thyroid type and the pituitary, comparable, as said, to the differences between a greyhound and a bull-dog, are dependent solely upon quant.i.tative variations in the general and local speeds of metabolism, among the cells.
DIVISION OF LABOR
Besides the antagonisms and co-operations between them, there are certain lines along which the glands, in their effects, specialize.
The thyroid, for instance, is concerned specially with the regulation of the shape, form and finish of an organ. The pituitary shines at the periods of developmental crises, determining them and modifying them.
It exerts the greatest influence upon the time of eruption of the teeth, both the temporary and the permanent, the onset of p.u.b.erty, the recurrence of menstruation in women, and the time of occurrence of labor. The interst.i.tial glands distribute the basis of the powers and limitations of masculinity and femininity. Abnormalities of these glands also affect the individual all along the line, in all of his aspects. So affected he may apparently change into a wholly different being. He may change in size, in the shape of his head, feet and hands, as well as in his habits, apt.i.tudes and dispositions. So he may find it necessary to purchase an entirely different size of hat, more commodious clothes, and newly fitting gloves and shoes. At the same time, his family, relatives and friends, discover that the erstwhile generous, frank, neat and punctual and liked, has become stingy and suspicious and slovenly and hated. And all because a gland has begun to undersecrete or to oversecrete. The transformation will be slight or marked, depending entirely upon the extent of impairment, positive or negative, of the gland involved.
But it is not only in the shaping of the normal individual's architecture that the internal secretions dominate. Over that subtle something known in all languages as vitality, expressive of the intensity of feeling, thought and reactions in cells, they rule supreme. Gay vivacity and grim determination, the temperament of a Louis XIV, and the soul of a Cromwell, are the crystallizations of these chemical substances acting upon the brain.
INTERNAL SECRETION VARIETIES
There is no better way of ill.u.s.trating the influence of the internal secretions upon the normal than the a.n.a.lysis of the variation of traits with variations in glandular predominances. The general build of an individual, his skeletal type, the proportion between the size of his arms and that of his legs, as well as that between his trunk and his lower extremities, whether he is to be tall, lanky and loutish, or short, squat and dumpy, are to be considered. Different facial types are the expressions of underlying endocrine differences.
The head and skull offer a number of clues to the controlling secretions in the blood and tissues. Whether the forehead is to be broad or narrow, the distance between the eyes, the character of the eyebrows, the shape and size and appearance of the eyes themselves, the mould of the nose and jaws and the peculiarities of the teeth, are all so determined. The skin, in its color, texture, the quant.i.ty and distribution of its fatty and other const.i.tuents, eruptions and weather reactions, is influenced. Also the mucous membranes, the color and l.u.s.tre and structure of the hair, as well as its general distribution and development, are hieroglyphics of the endocrine processes below the surface. Whether the muscles are ma.s.sive or spa.r.s.e, atrophied or hypertrophied, soft or hard, easily fatigable or not, bespeak conditions in the glandular chain. In short, we must regard the individual as an immensely complicated pattern of designs traced by the hormones as the primary etchers of his development.
Though it must be admitted that the number of unknown and unsolved relations in the pattern are still enormously great, enough has been established to make possible a rough working a.n.a.lysis of the particular, unique organism placed before us for examination as Mr.
Smith, Mrs. Jones, or Miss Smith-Jones.
WHAT IS THE NORMAL?
Anthropologists, from the beginning of anthropology, have battled in vain for a satisfactory inclusive definition, or, at least, description of the normal. With the introduction of the biometric method, the goal at last appeared within sight. A c.o.c.ked hat curve expressing the distribution and range of the normal looks formidable.
The attainable turned out a mirage, for the curves constructable by the measurement of traits of a population only proved the truth of the old axiom that all transitions and variations between extremes exist.
The Problem of the Normal seemed more elusive than ever. And the best that could be done for the elucidation of its mystery, was to apply and observe the law of averages.
From the endocrine standpoint, the reason for this becomes clear. The biometric method concerned itself with externals, with, as it were, symptoms. Since these external signs are but manifestations of the inner chemical reactions, of which the internal secretions are the determining reagents, or factors, with permutations and combinations possible in all directions, the diversity and variability of each individual and his traits stands explained and understandable. The normal, as the perfect or nearly perfect balance of forces in the organism, at any given moment, emerges as a more definite and real concept than that which would abstract it from a curve of variations.
Moreover, since the directive forces within the organism are pre-eminently the internal secretions, the normal becomes definable as their harmonious balancing or equilibrium, a state which tends not to undo (as the abnormal does) but to prolong itself.
The potential combinations and compensations, antagonisms and counteractions, attainable within the endocrine glands as an interlocking directorate, point the cause for the elusive quality of the normal. Tall men and short men, blonde women and dumpy women, lanky hatchet-faced people, stout moon-faced people, Falstaff and Queen Elizabeth, George Washington and Abraham Lincoln, Disraeli and Walt Whitman, Caesar and Alexander, as well as Mr. Smith and Miss Jones come within the range of the normal. There are all kinds and conditions and sorts of men and women, and all kinds and sorts and conditions of the normal, because an incalculable number of harmonious relations and interactions between the endocrines are possible, and do actually occur. The standard of the normal must obviously not be a single standard, but a series of standards, depending upon which glands predominate, and how the others adapt themselves to its predominance. Adrenal-centered types, thyroid-centered types, pituitary-centered types, thymus-centered types, as well as hyphenated compounds of these, such as the pituitary-adrenal types, exist as normals. They can be conceived of as normal types because they exist as normal types.
THE SKELETAL TYPES
Now men, for as long as we have any knowledge of their thoughts and cla.s.sifications and att.i.tudes, have been accustomed to first think of one another, to cla.s.sify and size one another as tall or short, slender or broad, thin or corpulent. The biological necessity, indeed, instinct of the one animal to relate the other animal to aggressive or harmless agencies in his surroundings, accounts for this. Relatively, of course, for all these modes of description imply offensive or defensive possibilities of the stimulus for the recorder in relation to himself. The interest in stature is fundamental, and has persisted in the most civilized, nations. The relationship of height and weight, as well as of length and breadth, to other physical traits, have formed the subject of scientific study. There is, for instance, the cla.s.sification of Bean, who divided mankind generally into two types, those of a medium size, stocky long legs and arms, large hands and feet, short trunk, and face large in comparison to the head (the meso-onto-morphs) and those who were either tall and slender, or small and delicate, with the smaller face, eyes close together, long, high, narrow nose, and trunk longer as compared with the extremities (the hyper-onto-morphs). Bean showed, too, that the hypers (to use a short word to contrast with the mesos) were present to the extent of almost a hundred per cent in a series of tuberculosis, and about ninety per cent in a series of central nervous system disease. All of which is exceedingly interesting and suggestive, but throws no light upon the underlying mechanisms of statures.
STATURE AND GROWTH
Stature is essentially determined by the growth of the long bones.
They are the pace-makers, and the muscles and soft tissues follow the pace they set. Now the primary determinant, catalyst or sensitizer of the growth of the long bones is the anterior pituitary. All statures should therefore be first scrutinized from the point of view of the pituitary. Individuals over six feet tall or under five feet five inches should be looked upon as having a pituitary trend. This pituitary trend may be primary, due to its own undergrowth or overgrowth, or it may be due to lack of inhibition from the s.e.x glands such as occurs in eunuchs and eunuchoids, or excessive or premature inhibition from them as happens in certain salacious dwarfs.
The long bones grow at a point of junction between the bone proper and an overlying layer of gristle or cartilage, known as the zone of ossification. It is upon this zone of ossification that the various growth influences appear to focus and concentrate their efforts, among them the internal secretions. After growth has been finished, that is, after adolescence, these zones of ossification close, so that growth is no longer possible unless they become reactivated. Upon the zone of ossification must act the pituitary, and indirectly the thyroid, the interst.i.tial cells, the thymus and the adrenals. Individuals oversized or undersized either belong to the pituitary type, or if hyphenated, have the pituitary as one of the dominants in their composition. The necessities of child-bearing determine a greater angle between trunk and lower extremities in the female. Underactivity of the pituitary, for instance, will prevent the development of the normal angle. The ratio in length of the upper limbs to the lower is a fairly constant relationship for each s.e.x normally Deviations occur with a break somewhere in the chain of cooperation of the internal secretions controlling the growth of bone.
HANDS, FINGERS AND TOES
The size and shape and general configuration of the hands, fingers and toes are details that tell an endocrine tale. Students of hands naturally have grouped them as the long slender and the short, broad, the bony and the well-filled out, the tapering fingers and the stumpy.
The character of a hand is determined anatomically by the length and breadth of the bones, the amount and distribution of fat, and the thickness and elasticity of the skin. Over these, the essential control lies in the pituitary and the thyroid. So we find that pituitary types have, when there is oversecretion, large bony, gross hands, spade-shaped, or when there is undersecretion, hands that are plump, with peculiarly tapering fleshy fingers. The hyperthyroid has long slender fingers, the subthyroid pudgy, coa.r.s.e, ugly foreshortened hands, often cold, and bluish.
FACIAL TYPES
An artist will see in a face the past history of generations, a narrative of the adventures of the blood, a record of tears and smiles, wrinkles and dimples, the victories and defeats of buried drudgery and romance. These signatures which the Faculty of Life have scribbled or engraved over it as upon a diploma, bespeak for him spiritual moments. To the student of the internal secretions the lines, expressions, att.i.tudes are important for they tell of the state of tensions and strains in the vegetative apparatus with which they are inseparably connected. It is when one comes to the consideration of the face as a complex of brows, eyes, nose, lips and jaws that he becomes most interested. For in the modeling and tone of every one of the features each of the endocrine glands has something to say. In consequence there has been described the hyperpituitary face, and the hyperthyroid face, the subthyroid face and the subpituitary face, the adrenal face, the eunuchoid face and the ovarian face and also the thymic.
To bring to mind an immediate complete image of the hyperthyroid face, one should think of Sh.e.l.ley. The oval shape of it, with the delicate modeling of all the features, the wide, high brow, the large, vivacious, prominent eyes with the glint of a divine fire in them and the sensitive lips all belong to the cla.s.sical picture. Generally flushed over the cheek-bones, there is undoubtedly a certain effeminate effect a.s.sociated with it. At least, it is the least animal and brutish of the faces of man.
On the other hand, the subthyroid face is that of the cretin and cretinoid idiot, in a mild degree. So characteristic that we recognize the portrait in the descriptions of Pliny in early Roman tunes and of Marco Polo in his Asiatic travels. Coa.r.s.eness, dullness, pudginess are its keynotes. Irregular features, tendency to wide separation of the eyes and pug nose, sallow, puffy complexion, waxy thickened nose and eyelids, deep-set, listless, lackl.u.s.tre eyebrows, and thick prominent lips comprise the catalogue of the physiognomy. On the whole, the sort of face one pa.s.ses in the street as stupid and common. But there are a number of fascinating and marvelous varieties of the stupid and common.
The adrenal face is most often dark or freckled. It tends to be irregularly broadish. It is hairy, one is struck forcibly. There is a low hair line, which makes the brow appear rather low, and there is a good deal of hair over the cheek bones. The adrenal type is round headed.
The face of the hyperpituitary is striking and pretty sharply defined.
It is long and narrow, with a tendency to prominence of the bony parts. Square, protruding jaw, high, thin, straight nose, emphasized eyebrows, and marked cheek-bones, comprise the leading points in its composition. On the other hand, the subpituitary is more rounded and trends toward the full moon effect, the chin recedes, the cheek-bones are buried under fat, the nose spreads more and is flatter. In its general expression, there is a complacence and tranquillity which is often mistaken for sleepiness, and often actually is dullness.
The eunuchoid face is usually fat with puffy eyelids. The skin is smooth and cool, marble-like often, poor in pigment and color.
Sometimes it is sallow, wrinkled and senile in a man in his early twenties. At others, it is distinctly feminine in its hairlessness, and the delicate texture of the skin, as well as in the clean-cut patterning of the features. Every gradient between premature senility and s.e.x inversion is encountered.
The thymic face frequently stamps its possessor at sight. Its owner has a smooth, soft skin, with little or no hair, and a dead white or "peaches-and-cream" complexion. One wonders, when unacquainted with the type, who the man's barber is, or where he learned to shave himself so well. It may be curiously velvety to the touch and swept by a faint sheen. Among children occur the most exquisite samples of the kind designated as the angelic child. The face is finely moulded and beautifully proportioned, features artistically chiselled, eyes blue or brown with long lashes, cheeks transparent with rapid, fleeting variations in coloring, thin lips, and oval chin. In the adult, the chin is receding, and the mouth seems underdeveloped in one variety.
THE TEETH
As closely connected with the internal secretions as are the bones of the face and the skull are the teeth. Tooth formation is essentially a modified bone formation. And as the bones of the face are influenced, so are the teeth influenced. But as each tooth is a miniature organ, inspectable by the eye as a unit, the action of the ductless glands is more obviously reflected for the observer to read. By their teeth shall ye know them. Upon the whole history of the evolution of each tooth, in the growth of the dental follicle and its walls, the fruition of the dentinal germ, the making of the enamel organ, the dental pulp, the cementum and the peridental membrane, the endocrines leave their mark.
There are certain general statements about the teeth and the internal secretions that can be made. The teeth of the thyroid types are pearly, glistening, small and regular; in other words, the teeth to which poets have devoted sonnets. The pituitary types have teeth that are large and square and irregular, with prominence of the middle incisors, and a marked separation or crowding of them. The interst.i.tial types have small irregular upper teeth, with turned, stumpy or missing lateral incisors. The thymus types have youthful, milky white teeth that are thin and translucent, and scalloped or crescentic at the grinding edge. The teeth of the adrenal type are all well-developed, tend to have a yellowish color, with a reddish tinge to the grinding surfaces.
The degree and regularity of development of the middle upper cutting, biting teeth, as distinguished from the grinding molars, the middle and lateral incisors, and the canines offer further guides to the endocrine const.i.tution a.n.a.lysis. The size of the central incisors seems to be directly proportional to the degree of pituitary predominance. On the other hand, the size and regularity of the lateral incisors seem proportional to the influence of the interst.i.tial cells. When these are inferior in the make-up of an individual, the lateral incisors are nearly always distorted. The size of the canines appears to be a measure of adrenal activity. Long sharply pointed canines mean well-functioning adrenal gland equipment to start in with, inherited from a bellicose progenitor.
No individual peculiarities of the teeth are accidental. Just as the absence of hair on the face in a man or a moustache effect in a woman stand for some definite stress or strain in the mechanics of interaction of the internal secretions, so likewise do variations in dent.i.tion, as to the time of eruption of the teeth, their position and quality, and their resistance to decay.
Proper balance between the thymus and pituitary will permit the eruption of the teeth within the normal time limits, both the milk teeth and the permanent teeth. When there is equilibrium between the pituitary and the gonads, the teeth will be regular in shape and position. Carious teeth, in children and adults, sometimes indicate endocrine imbalance. Thyroid and adrenal balance determines the resistance to decay of the molars. Early decay of the molars in children is significant of insufficiency of the thyroid. When the first permanent molar, which should appear in the upper arch in its usual position between the sixth or eighth years, does not, there has been a prenatal disturbance of the pituitary, according to Chayes and others. Rapid decay of the teeth in childhood should always call attention to the parathyroids.
In pregnancy, the teeth suffer particularly because of disturbances of the endocrines. The saying, "A tooth for every child," is said to have its equivalent in every language. The bicuspids and second permanent molars erupt around p.u.b.erty, when profound readjustments are going on among the glands of internal secretion. They consequently suffer with their abnormalities or divergences from type. The teeth thus furnish a good deal of information concerning the distribution of the balance of power among the hormones.
THE SKIN
The skin is influenced in its color, moisture, hairiness, texture, fat content and disease vulnerability by the endocrines. The question of color is very interesting, for it is probably the expression of the blending action of the different internal secretions. Davenport, the American student of heredity and eugenics, has shown that neither white nor black skins are either perfectly white or perfectly black, but are mixtures in various proportions of black, yellow, red and white. The exact percentages of the pigments in each particular skin, can be determined by means of a rotating disc. Thus a white person's skin may have the following composition:
Black 8% Red 50%